It opens with the female vocal group Tre' (Kimberly Cromartie, Rebecca Forsha and Maniko Williams) singing the traditional spiritual ' Mary Don't You Weep' in a church funeral setting, followed by the members of Bone Thugs-n-Harmony singing the main song in several settings, such as a church and a mountain top.

The music video was filmed on February 27–28, 1996. In 2008, 'Tha Crossroads' was ranked number 33 on VH1's '100 Greatest Songs of Hip Hop'. It has been certified double platinum in the United States and platinum in New Zealand. The song was a hit worldwide and reached the top of the US Billboard Hot 100 and the New Zealand Singles Chart on the latter chart, it was the most successful song of 1996. (After receiving their publishing rights from Ruthless Records.) In 2019, a version including other group member Flesh-n-Bone was released with the Bone Thugs-n-Harmony compilation album Lost Archives Vol 1. After receiving high praise for their song the group decided to make it their third single for their already released album, E. The song is performed by four of the group's members, ( Krayzie Bone, Layzie Bone, Bizzy Bone and Wish Bone).

The original song appears on the edited version of the album, though the European release has the original as track number 8 and the remix as track 18. It was dedicated to Bone's dead friend Wallace (Wally) Laird III, but after the death of Eazy-E they decided to remake it as 'Tha Crossroads'. 'Crossroad' originally debuted in 1995 on the E.

Bone thugs and harmony